Similar probabilistic distributions were developed to examine mammalian Cmax and an Acute to Therapeutic Ratio (ATR), a surrogate for mammalian therapeutic index that is similar to an Acute to Chronic Ratios (ACRs) commonly calculated for fish models.
All concepts result in similar classifications of the selected pharmaceuticals.
A similar organism, Ceriodaphnia dubia, has a shorter life cycle and therefore survival and reproductive endpoints may be established following 7 d of exposure.
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